Ontology highlight
ABSTRACT:
SUBMITTER: Marques BS
PROVIDER: S-EPMC7567893 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20201016 1
Conformational entropy can be an important element of the thermodynamics of protein functions such as the binding of ligands. The observed role for conformational entropy in modulating molecular recognition by proteins is in opposition to an often-invoked theory for the interaction of protein molecules with solvent water. The "solvent slaving" model predicts that protein motion is strongly coupled to various aspects of water such as bulk solvent viscosity and local hydration shell dynamics. Chan ...[more]