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Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection.

ABSTRACT: MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.

SUBMITTER: Yang J

PROVIDER: S-EPMC7568386 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection.

Yang Jing J Huang Xinmei X Liu Yuzhuo Y Zhao Dongmin D Han Kaikai K Zhang Lijiao L Li Yin Y Liu Qingtao Q

Veterinary research 20201017 1

MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways includin ...[more]

PMID: 33069243

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