Ontology highlight
ABSTRACT:
SUBMITTER: Sathyanarayanan U
PROVIDER: S-EPMC7568574 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Sathyanarayanan Udhayabhaskar U Musa Marina M Bou Dib Peter P Raimundo Nuno N Milosevic Ira I Krisko Anita A
Nature communications 20201016 1
Signs of proteostasis failure often entwine with those of metabolic stress at the cellular level. Here, we study protein sequestration during glucose deprivation-induced ATP decline in Saccharomyces cerevisiae. Using live-cell imaging, we find that sequestration of misfolded proteins and nascent polypeptides into two distinct compartments, stress granules, and Q-bodies, is triggered by the exhaustion of ATP. Both compartments readily dissolve in a PKA-dependent manner within minutes of glucose r ...[more]