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Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives.

ABSTRACT: A series of derivatives of trans-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4'phenyl)thiosemicarbazide (9) and of trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (10a-c) were synthesized from trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro-4,5-bis(hydrazenocarbonyl)isoxazole (8). The structures of the compounds were elucidated by both elemental and spectral (IR, NMR, and MS) analysis. Compound 9 shows activity against some bacterial species. No antibacterial activities were observed for compounds 10a-c. The antioxidant activity of the new compounds has been screened. Compound 9 showed higher antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2'-azino-bis(3-ethylbenzoline-6-sulfonic acid) diammonium salt methods.

SUBMITTER: Alshamari A 

PROVIDER: S-EPMC7570493 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives.

Alshamari Asma A   Al-Qudah Mahmoud M   Hamadeh Fedaa F   Al-Momani Lo'ay L   Abu-Orabi Sultan S  

Molecules (Basel, Switzerland) 20200918 18

A series of derivatives of <i>trans</i>-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4'phenyl)thiosemicarbazide (<b>9</b>) and of <i>trans</i>-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (<b>10a</b>-<b>c</b>) were synthesized from <i>trans</i>-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro-4,5-bis(hydrazenocarbonyl)isoxazole (<b>8</b>). The structures of the compounds were elucidated by both elemental and spectral (IR, NMR, and MS) analysis. Compound  ...[more]

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