Semaphorin 7a is a biomarker for recurrence in postpartum breast cancer.
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ABSTRACT:
SUBMITTER: Borges VF
PROVIDER: S-EPMC7572422 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Semaphorin 7a is a biomarker for recurrence in postpartum breast cancer.
Borges Virginia F VF Hu Junxiao J Young Chloe C Maggard Jaron J Parris Hannah J HJ Gao Dexiang D Lyons Traci R TR
NPJ breast cancer 20201019
Breast cancer is a global health threat and cases diagnosed in women during the years after childbirth, or postpartum breast cancers (PPBCs), have high risk for metastasis. In preclinical murine models, semaphorin 7a (SEMA7A) drives the metastatic potential of postpartum mammary tumors. Thus, we hypothesize that SEMA7A may drive metastasis of PPBC in women. We report that SEMA7A protein expression is increased in PPBCs compared to their nulliparous counterparts in our University of Colorado coho ...[more]
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