Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity.

ABSTRACT:

Purpose

Although advancements in cancer treatments using radiation therapy (RT) have led to improved outcomes, radiation-induced heart disease (RIHD) remains a significant source of morbidity and mortality in survivors of cancers in the chest. Currently, there are no diagnostic tests in clinical use due to a lack of understanding of the natural history and mechanisms of RIHD development. Few studies have examined the utility of using metabolomics to prospectively identify cancer survivors who are at risk of developing cardiotoxicity.

Methods

We analyzed plasma and left ventricle heart tissue samples collected from a cohort of male Sprague Dawley (SD) rats that were either sham irradiated or received fractionated doses (9 Gy per day × 5 days) of targeted X-ray radiation to th

SUBMITTER: Unger K 

PROVIDER: S-EPMC7572465 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature