Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC7572805 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Zhu Lan L Chen Xiaoyu X Abola Enrique E EE Jing Liang L Liu Wei W
Trends in pharmacological sciences 20200916 11
Rational drug discovery has greatly accelerated the development of safer and more efficacious therapeutics, assisted significantly by insights from experimentally determined 3D structures of ligands in complex with their targets. Serial crystallography (SX) with X-ray free-electron lasers has enabled structural determination using micrometer- or nanometer-size crystals. This technology, applied in the past decade to solve structures of notoriously difficult-to-study drug targets at room temperat ...[more]