Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis.
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ABSTRACT:
SUBMITTER: Hakkinen S
PROVIDER: S-EPMC7572920 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis.
Häkkinen Suvi S Chu Stephanie A SA Lee Suzee E SE
Neurobiology of disease 20200902
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong clinical, genetic and pathological overlap. This review focuses on the current understanding of structural, functional and molecular neuroimaging signatures of genetic FTD and ALS. We overview quantitative neuroimaging studies on the most common genes associated with FTD (MAPT, GRN), ALS (SOD1), and both (C9orf72), and summarize visual observations of images reported in the rarer genes (CHMP2B, TARDBP, FUS, OPTN, ...[more]
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