Ontology highlight
ABSTRACT:
SUBMITTER: Busselaar J
PROVIDER: S-EPMC7573232 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Busselaar Julia J Tian Sun S van Eenennaam Hans H Borst Jannie J
Frontiers in immunology 20201006
Persistent antigen exposure in chronic infection and cancer has been proposed to lead to cytotoxic T lymphocyte (CTL) "exhaustion", i.e., loss of effector function and disease control. Recent work identifies a population of poorly differentiated TCF-1<sup>+</sup>PD-1<sup>+</sup> CD8<sup>+</sup> T cells as precursors of the terminally exhausted CTL pool. These "predysfunctional" CTLs are suggested to respond to PD-1 targeted therapy by giving rise to a pool of functional CTLs. Supported by gene e ...[more]