Ontology highlight
ABSTRACT:
SUBMITTER: Lippmann ES
PROVIDER: S-EPMC7574179 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lippmann Ethan S ES Azarin Samira M SM Palecek Sean P SP Shusta Eric V EV
Fluids and barriers of the CNS 20201019 1
In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood-brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as ...[more]