Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.

ABSTRACT:

Background

The causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question from a genetic perspective to protect against these biases. We measured associations between genetic liability for high levels of inflammatory markers Interleukin-6 (IL-6) and C-reactive protein (CRP) on self-harm, and conducted a secondary analysis restricted to self-harm with suicidal intent.

Methods

We conducted two sample and multivariable Mendelian randomisation (MR) to assess the effects of IL-6 and CRP on self-harm utilising existing data and conducting new genome wide association studies to instrument IL-6 and CRP, and for the outcome of self-

SUBMITTER: Russell AE 

PROVIDER: S-EPMC7575900 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature