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Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19.

ABSTRACT: SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.

SUBMITTER: Valyaeva AA

PROVIDER: S-EPMC7576138 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19.

Valyaeva Anna A AA Zharikova Anastasia A AA Kasianov Artem S AS Vassetzky Yegor S YS Sheval Eugene V EV

Scientific reports 20201020 1

SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to de ...[more]

PMID: 33082395

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