Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC7577723 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Science advances 20201021 43
Progranulin (PGRN) is a secreted pleiotropic glycoprotein associated with the development of common neurodegenerative diseases. Understanding the pathophysiological role of PGRN may help uncover biological underpinnings. We performed a genome-wide association study to determine the genetic regulators of cerebrospinal fluid (CSF) PGRN levels. Common variants in region of <i>FAM171A2</i> were associated with lower CSF PGRN levels (rs708384, <i>P</i> = 3.95 × 10<sup>-12</sup>). This was replicated ...[more]