Ontology highlight
ABSTRACT:
SUBMITTER: Hook SC
PROVIDER: S-EPMC7578007 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Hook Sharon C SC Chadt Alexandra A Heesom Kate J KJ Kishida Shosei S Al-Hasani Hadi H Tavaré Jeremy M JM Thomas Elaine C EC
Scientific reports 20201021 1
Proteins involved in the spaciotemporal regulation of GLUT4 trafficking represent potential therapeutic targets for the treatment of insulin resistance and type 2 diabetes. A key regulator of insulin- and exercise-stimulated glucose uptake and GLUT4 trafficking is TBC1D1. This study aimed to identify proteins that regulate GLUT4 trafficking and homeostasis via TBC1D1. Using an unbiased quantitative proteomics approach, we identified proteins that interact with TBC1D1 in C2C12 myotubes including ...[more]