Synthesis and in vivo evaluation of a radiofluorinated ketone body derivative.
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ABSTRACT:
SUBMITTER: Mattingly SJ
PROVIDER: S-EPMC7580772 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Synthesis and <i>in vivo</i> evaluation of a radiofluorinated ketone body derivative.
Mattingly Stephanie J SJ Wuest Melinda M Fine Eugene J EJ Schirrmacher Ralf R Wuest Frank F
RSC medicinal chemistry 20200213 2
The ketone bodies d-beta-hydroxybutyric acid and acetoacetic acid represent the principal oxidative energy sources of most tissues when dietary glucose is scarce. An <sup>18</sup>F-labeled ketone body could be a useful tool for studying ketone body metabolism using positron emission tomography (PET). Here, we report the first radiofluorinated ketone body derivative (3<i>S</i>)-4-[<sup>18</sup>F]fluoro-3-hydroxybutyric acid ([<sup>18</sup>F]FBHB) as well as its enantiomer and l-beta-hydroxybutyri ...[more]
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