Ontology highlight
ABSTRACT:
SUBMITTER: Holmes AC
PROVIDER: S-EPMC7580943 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
PLoS pathogens 20201022 10
Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway, including attachment, internalization, and fusion. Herein, we review recent developments in the molecular understanding of alphavirus entry both in vitro and in vivo and how these advances might enable the design of therapeutics targeting this critical ...[more]