Ontology highlight
ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC7952414 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Ge Xinhong X Niture Suryakant S Lin Minghui M Cagle Patrice P Li P Andy PA Kumar Deepak D
Scientific reports 20210311 1
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which regulates tumor growth and survival. Our goal is to delineate the detailed oncogenic role of TNFAIP8 in skin cancer development and progression. Here we demonstrated that higher expression of TNFAIP8 is associated with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma development in patient tissues. Induction of TNFAIP8 expression by TNFα or by ectopic expression of TNFAIP8 in S ...[more]