Epigenetic alterations in skin homing CD4+CLA+ T cells of atopic dermatitis patients.
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ABSTRACT:
SUBMITTER: Acevedo N
PROVIDER: S-EPMC7582180 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Epigenetic alterations in skin homing CD4<sup>+</sup>CLA<sup>+</sup> T cells of atopic dermatitis patients.
Acevedo Nathalie N Benfeitas Rui R Katayama Shintaro S Bruhn Sören S Andersson Anna A Wikberg Gustav G Lundeberg Lena L Lindvall Jessica M JM Greco Dario D Kere Juha J Söderhäll Cilla C Scheynius Annika A
Scientific reports 20201022 1
T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations (CD4<sup>+</sup>, CD4<sup>+</sup>CD45RA<sup>+</sup> naïve, CD4<sup>+</sup>CLA<sup>+</sup>, and CD8<sup>+</sup>) from adult AD patients and healthy controls (HC). ...[more]
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