Ontology highlight
ABSTRACT:
SUBMITTER: Graham MS
PROVIDER: S-EPMC7582376 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Graham Maya S MS Mellinghoff Ingo K IK
International journal of molecular sciences 20200929 19
Pediatric high-grade glioma (pHGG) is the leading cause of cancer death in children. Despite histologic similarities, it has recently become apparent that this disease is molecularly distinct from its adult counterpart. Specific hallmark oncogenic histone mutations within pediatric malignant gliomas divide these tumors into subgroups with different neuroanatomic and chronologic predilections. In this review, we will summarize the characteristic molecular alterations of pediatric high-grade gliom ...[more]