Unknown

Dataset Information

0

Stereoselective syntheses of 3-dehydroxynaltrexamines and N-methyl-3-dehydroxynaltrexamines.


ABSTRACT: Methodology is presented for the synthesis of 6α/β-3-dehydroxynaltrexamines and 6α/β- N-methyl-3-dehydroxynaltrexamines. A stereoselective route is provided for each target compound while a novel one-pot method for the synthesis of 6 α/β-3-N-methyl-3-dehydroxynaltrexamines is also explored. These results enable the versatile and efficient preparation of key epoxymorphinan intermediates to facilitate future selective opioid ligand discovery and development.

SUBMITTER: Li M 

PROVIDER: S-EPMC7584067 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7961859 | biostudies-literature
| S-EPMC7545439 | biostudies-literature
| S-EPMC7007280 | biostudies-literature
| S-EPMC8397315 | biostudies-literature
| S-EPMC2665024 | biostudies-literature
| S-EPMC3148192 | biostudies-literature
| S-EPMC2650083 | biostudies-literature
| S-EPMC6017647 | biostudies-literature
| S-EPMC5820753 | biostudies-literature
| S-EPMC6641225 | biostudies-literature