Ontology highlight
ABSTRACT:
SUBMITTER: Ballard A
PROVIDER: S-EPMC5820753 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ballard Andrew A Ahmad Hiwa O HO Narduolo Stefania S Rosa Lucy L Chand Nikki N Cosgrove David A DA Varkonyi Peter P Asaad Nabil N Tomasi Simone S Buurma Niklaas J NJ Leach Andrew G AG
Angewandte Chemie (International ed. in English) 20171115 4
Racemization has a large impact upon the biological properties of molecules but the chemical scope of compounds with known rate constants for racemization in aqueous conditions was hitherto limited. To address this remarkable blind spot, we have measured the kinetics for racemization of 28 compounds using circular dichroism and <sup>1</sup> H NMR spectroscopy. We show that rate constants for racemization (measured by ourselves and others) correlate well with deprotonation energies from quantum m ...[more]