Ontology highlight
ABSTRACT:
SUBMITTER: Aqvist J
PROVIDER: S-EPMC7584337 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Åqvist Johan J Sočan Jaka J Purg Miha M
Biochemistry 20200925 40
The existence of temperature optima in enzyme catalysis that occur before protein melting sets in can be described by different types of kinetic models. Such optima cause distinctly curved Arrhenius plots and have, for example, been observed in several cold-adapted enzymes from psychrophilic species. The two main explanations proposed for this behavior either invoke conformational equilibria with inactive substrate-bound states or postulate differences in heat capacity between the reactant and t ...[more]