Ontology highlight
ABSTRACT:
SUBMITTER: Harami GM
PROVIDER: S-EPMC7584906 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20201005 42
Bacterial single-stranded (ss)DNA-binding proteins (SSB) are essential for the replication and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a highly conserved C-terminal peptide (CTP) motif that mediates a wide array of protein-protein interactions with DNA-metabolizing proteins. Here we show that the <i>Escherichia coli</i> SSB protein forms liquid-liquid phase-separated condensates in cellular-like condition ...[more]