Ontology highlight
ABSTRACT:
SUBMITTER: Zhuge Y
PROVIDER: S-EPMC7586427 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhuge Yingzhi Y Zhang Jian J Qian Fanyu F Wen Zhengwang Z Niu Chao C Xu Ke K Ji Hao H Rong Xing X Chu Maoping M Jia Chang C
International journal of biological sciences 20200821 14
Normally, smooth muscle cells (SMCs) are localized in the tunica media of the vasculature, where they take responsibility for vascular contraction and extracellular matrix (ECM) generation. SMCs also play a significant role in obedience and elastic rebound of the artery in response to the haemodynamic condition. However, under pathological or stressed conditions, phenotype switching from contractile to synthetic state or other cell types will occur in SMCs to positively or negatively contribute ...[more]