Ontology highlight
ABSTRACT:
SUBMITTER: Tietze A
PROVIDER: S-EPMC7586950 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20200625 19
Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2-electron reduction of the enzyme-bound thioester releasing the generated peptides as C-terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde-generating minimal NRPS termed ATRed in entomopathogenic Xenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed ...[more]