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Preparation of Functionalized ?,?-Unsaturated Sulfonamides via Olefin Cross-Metathesis.

ABSTRACT: The synthesis of functionalized ?,?-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda-Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan.

SUBMITTER: Wozniak L

PROVIDER: S-EPMC7588130 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis.

Woźniak Łukasz Ł Rajkiewicz Adam A AA Monsigny Louis L Kajetanowicz Anna A Grela Karol K

Organic letters 20200617 13

The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda-Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan. ...[more]

PMID: 32610933

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