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Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes.

ABSTRACT: An efficient [4 + 2] benzannulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes was achieved under metal-free reaction conditions selectively delivering a wide range of polyfunctional benzenes in high yields respectively (up to 94% yield).

SUBMITTER: Jia Q

PROVIDER: S-EPMC9055964 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Direct access to multi-functionalized benzenes <i>via</i> [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes.

Jia Qianfa Q Lan Yunfei Y Ye Xin X Lin Yinhe Y Ren Qiao Q

RSC advances 20200806 49

An efficient [4 + 2] benzannulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes was achieved under metal-free reaction conditions selectively delivering a wide range of polyfunctional benzenes in high yields respectively (up to 94% yield). ...[more]

PMID: 35521133

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