Left atrial appendage closure in patients with a reduced left ventricular ejection fraction: results from the multicenter German LAARGE registry.

ABSTRACT: BACKGROUND:Interventional left atrial appendage closure (LAAC) effectively prevents thromboembolic events in atrial fibrillation patients. Impaired left ventricular ejection fraction (LVEF) increases not only the thromboembolic risk but also the complication rates of cardiac interventions. The LAAC procedure's benefit in patients with an impaired LVEF, therefore, has yet to be investigated. METHODS:LAARGE is a prospective, non-randomized registry depicting the clinical reality of LAAC in Germany. Procedure was conducted with different standard commercial devices, and follow-up period was one year. In the sense of an as-treated analysis, patients with started procedure and documented LVEF were selected from the whole database. RESULTS:619 patients from 37 centers were categorized into one of three groups: LVEF?>?55% (56%),?36-55% (36%), and???35% (8%). Prevalence of cardiovascular comorbidity increased with LVEF reduction (p?

SUBMITTER: Fastner C 

PROVIDER: S-EPMC7588387 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature