Osteopontin binds ICOSL promoting tumor metastasis.
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ABSTRACT:
SUBMITTER: Raineri D
PROVIDER: S-EPMC7588454 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Osteopontin binds ICOSL promoting tumor metastasis.
Raineri Davide D Dianzani Chiara C Cappellano Giuseppe G Maione Federica F Baldanzi Gianluca G Iacobucci Ilaria I Clemente Nausicaa N Baldone Giulia G Boggio Elena E Gigliotti Casimiro L CL Boldorini Renzo R Rojo Josè M JM Monti Maria M Birolo Leila L Dianzani Umberto U Chiocchetti Annalisa A
Communications biology 20201026 1
ICOSL/ICOS are costimulatory molecules pertaining to immune checkpoints; their binding transduces signals having anti-tumor activity. Osteopontin (OPN) is here identified as a ligand for ICOSL. OPN binds a different domain from that used by ICOS, and the binding induces a conformational change in OPN, exposing domains that are relevant for its functions. Here we show that in vitro, ICOSL triggering by OPN induces cell migration, while inhibiting anchorage-independent cell growth. The mouse 4T1 b ...[more]
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