Ontology highlight
ABSTRACT:
SUBMITTER: Khailaie S
PROVIDER: S-EPMC7588844 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Khailaie Sahamoddin S Montaseri Ghazal G Meyer-Hermann Michael M
iScience 20201012 11
Regulatory T cells (Treg) are suppressor cells that control self-reactive and excessive effector conventional T helper cell (Tconv) responses. Breakdown of the balance between Tregs and Tconvs is a hallmark of autoimmune and inflammatory diseases. Interleukin-2 (IL-2) is a growth factor for both populations and subtle leverage to restore the healthy immune balance in IL-2 therapy. By using a mechanistic mathematical model, we introduced an adaptive control strategy to design the minimal therapeu ...[more]