Ontology highlight
ABSTRACT:
SUBMITTER: Pecan P
PROVIDER: S-EPMC7589052 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Pečan Peter P Hambalkó Szabolcs S Ha Van Thai VT Nagy Csilla T CT Pelyhe Csilla C Lainšček Duško D Kenyeres Bence B Brenner Gábor B GB Görbe Anikó A Kittel Ágnes Á Barteková Monika M Ferdinandy Péter P Manček-Keber Mateja M Giricz Zoltán Z
International journal of molecular sciences 20201016 20
Cardioprotection against ischemia/reperfusion injury is still an unmet clinical need. The transient activation of Toll-like receptors (TLRs) has been implicated in cardioprotection, which may be achieved by treatment with blood-derived extracellular vesicles (EVs). However, since the isolation of EVs from blood takes considerable effort, the aim of our study was to establish a cellular model from which cardioprotective EVs can be isolated in a well-reproducible manner. EV release was induced in ...[more]