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Photo-Induced Ruthenium-Catalyzed C-H Arylations at Ambient Temperature.

ABSTRACT: Ambient temperature ruthenium-catalyzed C-H arylations were accomplished by visible light without additional photocatalysts. The robustness of the ruthenium-catalyzed C-H functionalization protocol was reflected by a broad range of sensitive functional groups and synthetically useful pyrazoles, triazoles and sensitive nucleosides and nucleotides, as well as multifold C-H functionalizations. Biscyclometalated ruthenium complexes were identified as the key intermediates in the photoredox ruthenium catalysis by detailed computational and experimental mechanistic analysis. Calculations suggested that the in situ formed photoactive ruthenium species preferably underwent an inner-sphere electron transfer.

SUBMITTER: Korvorapun K

PROVIDER: S-EPMC7589283 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Photo-Induced Ruthenium-Catalyzed C-H Arylations at Ambient Temperature.

Korvorapun Korkit K Struwe Julia J Kuniyil Rositha R Zangarelli Agnese A Casnati Anna A Waeterschoot Marjo M Ackermann Lutz L

Angewandte Chemie (International ed. in English) 20200817 41

Ambient temperature ruthenium-catalyzed C-H arylations were accomplished by visible light without additional photocatalysts. The robustness of the ruthenium-catalyzed C-H functionalization protocol was reflected by a broad range of sensitive functional groups and synthetically useful pyrazoles, triazoles and sensitive nucleosides and nucleotides, as well as multifold C-H functionalizations. Biscyclometalated ruthenium complexes were identified as the key intermediates in the photoredox ruthenium ...[more]

PMID: 32662573

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