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Photo-Induced Ruthenium-Catalyzed C-H Arylation at Ambient Temperature.

ABSTRACT: Ambient temperature ruthenium-catalyzed C-H arylations were accomplished by visible light without additional photocatalysts. The robustness of the ruthenium-catalyzed C-H functionalization protocol was reflected by a broad range of sensitive functional groups and synthetically useful pyrazoles, triazoles and sensitive nucleosides and nucleotides, as well as multifold C-H functionalizations. Biscyclometalated ruthenium complexes were identified as the key intermediates in the photoredox ruthenium catalysis by detailed computational and experimental mechanistic analysis. Calculations suggested that the in-situ formed photoactive ruthenium species preferably underwent an inner-sphere electron transfer.

SUBMITTER: Korvorapun K

PROVIDER: S-EPMC7589283 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Photo-Induced Ruthenium-Catalyzed C-H Arylations at Ambient Temperature.

Korvorapun Korkit K Struwe Julia J Kuniyil Rositha R Zangarelli Agnese A Casnati Anna A Waeterschoot Marjo M Ackermann Lutz L

Angewandte Chemie (International ed. in English) 20200817 41

Ambient temperature ruthenium-catalyzed C-H arylations were accomplished by visible light without additional photocatalysts. The robustness of the ruthenium-catalyzed C-H functionalization protocol was reflected by a broad range of sensitive functional groups and synthetically useful pyrazoles, triazoles and sensitive nucleosides and nucleotides, as well as multifold C-H functionalizations. Biscyclometalated ruthenium complexes were identified as the key intermediates in the photoredox ruthenium ...[more]

PMID: 32662573

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