Ontology highlight
ABSTRACT:
SUBMITTER: Holle J
PROVIDER: S-EPMC7591021 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Holle Johannes J Kirchner Marietta M Okun Jürgen J Bayazit Aysun K AK Obrycki Lukasz L Canpolat Nur N Bulut Ipek Kaplan IK Azukaitis Karolis K Duzova Ali A Ranchin Bruno B Shroff Rukshana R Candan Cengiz C Oh Jun J Klaus Günter G Lugani Francesca F Gimpel Charlotte C Büscher Rainer R Yilmaz Alev A Baskin Esra E Erdogan Hakan H Zaloszyc Ariane A Özcelik Gül G Drozdz Dorota D Jankauskiene Augustina A Nobili Francois F Melk Anette A Querfeld Uwe U Schaefer Franz F
PloS one 20201027 10
The uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism and a decline in renal excretion. Despite of solid experimental evidence for nephrotoxic effects, the impact of uremic toxins on the progression of CKD has not been investigated in representative patient cohorts. In this analysis, IS and pCS serum concentrations were measured in 604 pediatric participants (mean eGFR of 27 ...[more]