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Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.

ABSTRACT: Severe malaria (SM) caused by Plasmodium falciparum (Pf) infection has been associated with life-threatening anemia, metabolic acidosis, cerebral malaria and multiorgan dysfunction. It may lead to death if not treated promptly. RNASE 3 has been linked to Pf growth inhibition and its polymorphisms found associated with SM and cerebral malaria in African populations. This study aimed to assess the association of RNASE 3 polymorphisms with SM in an Indian population. RNASE 3 gene and flanking regions were amplified followed by direct DNA sequencing in 151 Indian patients who visited Wenlock District Government Hospital, Mangalore, Karnataka, India. Allele, genotype and haplotype frequencies were compared between patients with SM (n?=?47) and uncomplicated malaria (UM; n?=?104). Homozygous mutant genotype was only found for rs2233860 (+?499G?>?C) polymorphism (?A), rs2073342 (+?371C?>?G) and rs2233860 (+?499G?>?C) polymorphisms was correlated significantly with SM patients (OR?=?3.03; p?=?0.008) after Bonferroni correction. A haplotype of RNASE 3 gene was found associated with an increased risk of SM and confirming that RNASE 3 gene plays a role in susceptibility to SM.

SUBMITTER: Mukhi B

PROVIDER: S-EPMC7591695 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.

Mukhi Benudhar B Gupta Himanshu H Wassmer Samuel C SC Anvikar Anupkumar R AR Ghosh Susanta Kumar SK

Molecular biology reports 20201028 11

Severe malaria (SM) caused by Plasmodium falciparum (Pf) infection has been associated with life-threatening anemia, metabolic acidosis, cerebral malaria and multiorgan dysfunction. It may lead to death if not treated promptly. RNASE 3 has been linked to Pf growth inhibition and its polymorphisms found associated with SM and cerebral malaria in African populations. This study aimed to assess the association of RNASE 3 polymorphisms with SM in an Indian population. RNASE 3 gene and flanking regio ...[more]

PMID: 33113080

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Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.

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Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.

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