The Genetics of Aging: A Vertebrate Perspective.
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ABSTRACT:
SUBMITTER: Singh PP
PROVIDER: S-EPMC7592626 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
The Genetics of Aging: A Vertebrate Perspective.
Singh Param Priya PP Demmitt Brittany A BA Nath Ravi D RD Brunet Anne A
Cell 20190301 1
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is more complex in vertebrates because of their specialized systems. This Review discusses advances in the genetic regulation of aging in vertebrates from work in mice, humans, and organisms with exceptional lifespans. We highlight challenges for the future, including sex-dependent differences in lifespan and the interplay between genes and envi ...[more]
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