Ontology highlight
ABSTRACT:
SUBMITTER: Dibus M
PROVIDER: S-EPMC7594087 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20201020 20
Protein kinase N3 (PKN3) is a serine/threonine kinase implicated in tumor progression of multiple cancer types, however, its substrates and effector proteins still remain largely understudied. In the present work we aimed to identify novel PKN3 substrates in a phosphoproteomic screen using analog sensitive PKN3. Among the identified putative substrates we selected ARHGAP18, a protein from RhoGAP family, for validation of the screen and further study. We confirmed that PKN3 can phosphorylate ARHG ...[more]