Ontology highlight
ABSTRACT:
SUBMITTER: Moroney JB
PROVIDER: S-EPMC7595102 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Moroney Justin B JB Vasudev Anusha A Pertsemlidis Alexander A Zan Hong H Casali Paolo P
Nature communications 20201028 1
Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B cells (NBC), IgD<sup>+</sup> unswitched (unsw)MBCs and IgG<sup>+</sup> or IgA<sup>+</sup> class-switched (sw)MBCs from humans of different age, sex and race. Conserved antibody variable gene expression indicates that MBCs emerge through unbiased selection from NBCs. Integrative analyses of mRNAs, miRNAs, lncRNAs, chromati ...[more]