Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids.

ABSTRACT: We aimed to evaluate methods of extracting optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer (GCIPL) thickness measurements over retinal locations corresponding to standard visual field (VF) test grids. A custom algorithm was developed to automatically extract GCIPL thickness measurements from locations corresponding to Humphrey Field Analyser 10-2 and 30-2 test grids over Goldmann II, III and V stimulus sizes from a healthy cohort of 478 participants. Differences between GCIPL thickness measurements based on VF test grids (VF-based paradigms) and the 8?×?8 grid, as per instrument review software, were analyzed, as were impacts of fovea to optic disc tilt and areas over which GCIPL thickness measurements were extracted. Significant differences between the VF-based paradigms and the 8?×?8 grid were observed at up to 55% of locations across the macula, with the greatest deviations at the fovea (median 25.5 ?m, 95% CI 25.24-25.72 ?m, P?

SUBMITTER: Tong J 

PROVIDER: S-EPMC7595126 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature