A non-enveloped arbovirus released in lysosome-derived extracellular vesicles induces super-infection exclusion.
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ABSTRACT:
SUBMITTER: Labadie T
PROVIDER: S-EPMC7595637 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
A non-enveloped arbovirus released in lysosome-derived extracellular vesicles induces super-infection exclusion.
PLoS pathogens 20201019 10
Recent developments on extracellular vesicles (EVs) containing multiple virus particles challenge the rigid definition of non-enveloped viruses. However, how non-enveloped viruses hijack cell machinery to promote non-lytic release in EVs, and their functional roles, remain to be clarified. Here we used Bluetongue virus (BTV) as a model of a non-enveloped arthropod-borne virus and discovered that the majority of viruses are released in EVs. Based on the cellular proteins detected in these EVs, an ...[more]
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