Ontology highlight
ABSTRACT:
SUBMITTER: Boylan M
PROVIDER: S-EPMC7595690 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Boylan Michael M Anderson Matthew J MJ Ornitz David M DM Lewandoski Mark M
Development (Cambridge, England) 20201019 21
The closure of the embryonic ventral body wall in amniotes is an important morphogenetic event and is essential for life. Defects in human ventral wall closure are a major class of birth defect and a significant health burden. Despite this, very little is understood about how the ventral body wall is formed. Here, we show that fibroblast growth factor (FGF) ligands FGF8, FGF17 and FGF18 are essential for this process. Conditional mouse mutants for these genes display subtle migratory defects in ...[more]