Deconstructive Functionalizations of Unstrained Carbon-Nitrogen Cleavage Enabled by Difluorocarbene.

ABSTRACT: Transition-metal- or oxidant-promoted deconstructive functionalizations of noncyclic carbon-nitrogen bonds are well established, usually only leaving one moiety functionalized toward the final product. In contrast, concomitant C- and N-functionalizations via the unstrained C(sp³)-N bond under metal- and oxidant-free conditions are very rare, which would favorably confer versatility and product diversity. Disclosed herein is the first difluorocarbene-induced deconstructive functionalizations embodying successive C(sp³)-N bond cleavage of cyclic amines and synchronous functionalization of both constituent atoms which would be preserved in the eventual molecular outputs under transition-metal-free and oxidant-free conditions. Correspondent access to deuterated formamides

SUBMITTER: Su J 

PROVIDER: S-EPMC7596867 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature