Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications.

ABSTRACT:

Background

Tumor microenvironment and its interaction with neuroendocrine modulators contribute to prostate carcinogenesis and progression.

Objective

We sought to define the transcriptomic and clinical implications of neuropeptide Y (NPY) expression in prostate cancer progression.

Design, setting, and participants

Genome-wide expression profiling of three localized prostate cancer (total n=18818) and five metastatic castrate-resistant prostate cancer (mCRPC; total n=495) cohorts was used to characterize NPY expression. All men underwent radical prostatectomy (RP) for localized prostate cancer.

Outcome measurements and statistical analysis

Patients were grouped into those with low NPY and high NPY based on NPY expression. Associations between these groups and hi

SUBMITTER: Alshalalfa M 

PROVIDER: S-EPMC7597937 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature