Ontology highlight
ABSTRACT:
SUBMITTER: Giampieri R
PROVIDER: S-EPMC7598185 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Giampieri Riccardo R Cantini Luca L Giglio Enrica E Bittoni Alessandro A Lanese Andrea A Crocetti Sonia S Pecci Federica F Copparoni Cecilia C Meletani Tania T Lenci Edoardo E Lupi Alessio A Baleani Maria Giuditta MG Berardi Rossana R
Cancers 20200923 10
Colorectal cancer is characterized by high incidence worldwide. Despite increased awareness and early diagnosis thanks to screening programmes, mortality remains high, particularly for patients with metastatic involvement. Immune checkpoint inhibitors or poly (ADP-ribose) polymerase (PARP)-inhibitors have met with disappointing results when used in this setting, opposed to other malignancies. New drugs with different mechanisms of action are needed in this disease. Drug repurposing might offer n ...[more]