Unknown

Dataset Information

0

Succinivibrionaceae is dominant family in fecal microbiota of Behcet's Syndrome patients with uveitis.


ABSTRACT: Behçet's Syndrome (BS) is a multisystem vasculitis with various clinical manifestations. Pathogenesis is unclear, but studies have shown genetic factors, innate immunity and autoinflammation to have an important role in the disease course. Diversity in the microbial community of gut microbiota may significantly contribute to the activation of the innate immune system. The clinical features of BS present themselves in clusters and each cluster may be a consequence of different disease mechanisms. For this reason we aimed to investigate the gut microbiota of BS patients with uveitis. In addition to healthy controls, we have aimed to compare the gut microbiota of BS with that of Familial Mediterranean Fever (FMF) and Crohn's Disease (CD) as both diseases have innate and autoinflammatory features in their pathogenesis. Seven patients with BS, 12 patients with FMF, 9 patients with CD and 16 healthy controls (HC) were included in the study. Total genomic DNAs were isolated from fecal samples of the patients. Partial 16S rRNA gene was sequenced using the PGM Ion Torrent (Thermo Fisher Scientific, Waltham, MA, USA) for microbiota analysis. Statistical analysis showed that significant differences were detected on the microbial community of four groups. Succinivibrionaceae is dominant and the signature family, whereas Bacteroides was absent in BS patients.

SUBMITTER: Tecer D 

PROVIDER: S-EPMC7598488 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Succinivibrionaceae is dominant family in fecal microbiota of Behçet's Syndrome patients with uveitis.

Tecer Duygu D   Gogus Feride F   Kalkanci Ayse A   Erdogan Merve M   Hasanreisoglu Murat M   Ergin Çagri Ç   Karakan Tarkan T   Kozan Ramazan R   Coban Seda S   Diker Kadir Serdar KS  

PloS one 20201030 10


Behçet's Syndrome (BS) is a multisystem vasculitis with various clinical manifestations. Pathogenesis is unclear, but studies have shown genetic factors, innate immunity and autoinflammation to have an important role in the disease course. Diversity in the microbial community of gut microbiota may significantly contribute to the activation of the innate immune system. The clinical features of BS present themselves in clusters and each cluster may be a consequence of different disease mechanisms.  ...[more]

Similar Datasets

| S-EPMC3855989 | biostudies-literature
| S-EPMC6200478 | biostudies-other
| S-EPMC7563889 | biostudies-literature
| S-EPMC7900992 | biostudies-literature
| S-EPMC8043080 | biostudies-literature
| S-EPMC3659956 | biostudies-other
| S-EPMC5045147 | biostudies-literature
| S-EPMC5637308 | biostudies-literature
| S-EPMC8603515 | biostudies-literature
| S-EPMC6969101 | biostudies-literature