Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival.
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ABSTRACT:
SUBMITTER: Timmins IR
PROVIDER: S-EPMC7599247 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival.
Timmins Iain R IR Zaccardi Francesco F Nelson Christopher P CP Franks Paul W PW Yates Thomas T Dudbridge Frank F
Communications biology 20201030 1
Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace in 450,967 European ancestry UK Biobank participants. We identify 70 independent associated loci (P < 5 × 10<sup>-8</sup>), 11 of which are novel. We estimate the SNP-based heritability as 13.2% (s.e. ...[more]
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