Ontology highlight
ABSTRACT:
SUBMITTER: La QT
PROVIDER: S-EPMC7600325 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
La Que T QT Ren Binhai B Logan Grant J GJ Cunningham Sharon C SC Khandekar Neeta N Nassif Najah T NT O'Brien Bronwyn A BA Alexander Ian E IE Simpson Ann M AM
Cells 20201002 10
Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (<i>INS-FUR</i>) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of glucose tolerance and pancreatic transdifferentiation (PT), due to the expression of beta (β)-cell transcription factors (β-TFs). The present study aimed to determine whether we could similarly reverse diabetes in the non-obese diabetic (NOD) ...[more]