Ontology highlight
ABSTRACT:
SUBMITTER: Wilkinson NA
PROVIDER: S-EPMC7600381 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Wilkinson Nicole A NA Mnuskin Katherine S KS Ashton Nicholas W NW Ashton Nicholas W NW Woodgate Roger R
Cancers 20201002 10
Many endogenous and exogenous factors can induce genomic instability in human cells, in the form of DNA damage and mutations, that predispose them to cancer development. Normal cells rely on DNA damage bypass pathways such as translesion synthesis (TLS) and template switching (TS) to replicate past lesions that might otherwise result in prolonged replication stress and lethal double-strand breaks (DSBs). However, due to the lower fidelity of the specialized polymerases involved in TLS, the activ ...[more]