Ontology highlight
ABSTRACT:
SUBMITTER: Eoff RL
PROVIDER: S-EPMC2948923 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Eoff Robert L RL Choi Jeong-Yun JY Guengerich F Peter FP
Journal of nucleic acids 20100926
DNA is a chemically reactive molecule that is subject to many different covalent modifications from sources that are both endogenous and exogenous in origin. The inherent instability of DNA is a major obstacle to genomic maintenance and contributes in varying degrees to cellular dysfunction and disease in multi-cellular organisms. Investigations into the chemical and biological aspects of DNA damage have identified multi-tiered and overlapping cellular systems that have evolved as a means of sta ...[more]