Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells.

ABSTRACT: The insulin resistance state of pancreatic ?-cells seems to be related to glucagon hypersecretion in type 2 diabetes. Treatment that can improve the insulin sensitivity of ?-cells could control glucagon levels in patients with diabetes mellitus. The aim of this study was to investigate the preventive role of D-chiro-inositol (DCI), which has insulin receptor-sensitizer effects on insulin signaling pathways and glucagon secretion in pancreatic ?-TC1 clone 6 cells. Cells were chronically treated with palmitate to induce insulin resistance in the presence/absence of DCI. DCI treatment improved the insulin signaling pathway and restored insulin-mediated glucagon suppression in ?-TC1-6 cells exposed to palmitate. These results indicate that DCI treatment prevents the insulin resistance of ?-TC1-6 cells chronically exposed to palmitate. Our data provide evidence that DCI could be useful to improve the insulin sensitivity of pancreatic ?-cells in diabetes treatment.

SUBMITTER: Filippello A 

PROVIDER: S-EPMC7601246 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature