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Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

ABSTRACT: Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favourable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated.

SUBMITTER: Kourakis S

PROVIDER: S-EPMC7602023 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

Kourakis Stephanie S Timpani Cara A CA de Haan Judy B JB Gueven Nuri N Fischer Dirk D Rybalka Emma E

Pharmaceuticals (Basel, Switzerland) 20201013 10

Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with fa ...[more]

PMID: 33066228

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